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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T16961 | Supinoxin | RX-5902 | Apoptosis , DNA/RNA Synthesis |
Supinoxin (RX-5902) is an orally active inhibitor of phosphorylated-p68 RNA helicase and a potent first-in-class anti-cancer agent. Supinoxin induces cell apoptosis and inhibits the growth of TNBC cancer cell lines (IC50... | |||
T9168 | NSC 617145 | NSC617145,NSC-617145 | DNA/RNA Synthesis |
NSC 617145 (NSC617145) is an inhibitor of WRN helicase that inhibits the ATPase, but not exonuclease, activity of WRN helicase in a concentration-dependent manner. | |||
T5413 | ML216 | CID-49852229 | DNA/RNA Synthesis |
ML216 (CID-49852229) is a small molecule inhibitor of BLM helicase (IC50: 1.8 μM). It showed 28-fold selective against the related helicases RECQ1, RECQ5, and E. coli UvrD (IC50s > 50 μM). | |||
T2275 | YK-4-279 | Apoptosis , DNA/RNA Synthesis | |
YK 4-279, an inhibitor of RNA Helicase A (RHA), binds to the oncogenic transciption factor EWS-FLI1. | |||
T82568 | DHX9-IN-2 | DNA/RNA Synthesis | |
DHX9-IN-2 is an inhibitor targeting ATP-dependent RNA de-helicase A (DHX9) with anticancer and antitumor activity for cancer research. | |||
T6970 | RK33 | RK-33,RK 33 | COX |
RK33 (RK 33) is a first-in-class small molecule inhibitor of DDX3 (a RNA helicase) and causes G1 cell cycle arrest, induces apoptosis, and promotes radiation sensitization in DDX3-overexpressing cells. | |||
T22282 | Brr2-IN-3 | Brr2 Inhibitor 9,Brr2 Inhibitor C9 | Others |
Brr2-IN-3 (Brr2 Inhibitor C9) is an allosteric inhibitor of the spliceosomal RNA helicase Brr2. Brr2 is implicated in autosomal-dominant retinitis pigmentosa (a group of progressive retinal degenerative disorders). | |||
T10848 | CMLD012073 | Others | |
T82569 | DHX9-IN-1 | ||
DHX9-IN-1 is a potent ATP-dependent RNA helicase A (DHX9) inhibitor, exhibiting an IC50 of 9.45 nM and demonstrating antitumor activity [1]. |
カタログ番号 | 製品名 | Species | Expression System |
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TMPH-00974 | DHX9 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
DHX9 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli. | |||
TMPH-01900 | DDX5 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
DDX5 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 74.1 kDa and the accession number is P17844. | |||
TMPH-00980 | DHX33 Protein, Human, Recombinant (His) | Human | E. coli |
DHX33 Protein, Human, Recombinant (His) is expressed in E. coli. | |||
TMPH-02133 | DDX39B Protein, Human, Recombinant (GST) | Human | E. coli |
Involved in nuclear export of spliced and unspliced mRNA. Assembling component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mR... | |||
TMPH-01902 | DDX60 Protein, Human, Recombinant (His) | Human | E. coli |
Positively regulates DDX58/RIG-I- and IFIH1/MDA5-dependent type I interferon and interferon inducible gene expression in response to viral infection. Binds ssRNA, dsRNA and dsDNA and can promote the binding of DDX58/RIG-... | |||
TMPH-00979 | DDX3Y Protein, Human, Recombinant (His & Myc) | Human | Baculovirus Insect Cells |
DDX3Y Protein, Human, Recombinant (His & Myc) is expressed in Baculovirus. | |||
TMPH-00976 | DDX19A Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
DDX19A Protein, Human, Recombinant (His & SUMO) is expressed in E. coli. | |||
TMPH-00977 | DDX3X Protein, Human, Recombinant (B2M & His) | Human | E. coli |
DDX3X Protein, Human, Recombinant (B2M & His) is expressed in E. coli. | |||
TMPH-00978 | DDX3X Protein, Human, Recombinant (His & Myc) | Human | Baculovirus Insect Cells |
DDX3X Protein, Human, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 77 kDa and the accession number is O00571. | |||
TMPH-00973 | DHX36 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
DHX36 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 18.2 kDa and the accession number is Q9H2U1. | |||
TMPH-00975 | DDX1 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
DDX1 Protein, Human, Recombinant (His & Myc) is expressed in E. coli. | |||
TMPH-01901 | DDX53 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
N/A. DDX53 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 76.2 kDa and the accession number is Q86TM3. | |||
TMPY-00323 | Hepatitis C virus (HCV-1a) NS3 protease/helicase immunodominant region Protein (aa 1356-1459, GST) | HCV | E. coli |
HCV NS3 displays three enzymatic activities: serine protease, NTPase, and RNA helicase. HCV NS3 serine protease, in association with NS4A, is responsible for the cleavages of NS3-NS4A, NS4A-NS4B, NS4B-NS5A, and NS5A-NS5B... | |||
TMPH-01306 | EIF4A1 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary str... | |||
TMPJ-01450 | SARS-CoV-2 Helicase Protein (His & MBP) | SARS-CoV-2 | E. coli |
The non—structural protein 13 (nsp13) of SARS—CoV 2 is a helicase that separates double—stranded RNA or DNA with a 5'—3' polarity, using the energy of nucleotide hydrolysis. A basic biochemical characterization of nsp13 ... | |||
TMPY-05752 | SARS-CoV-2 3CLpro/3C-like protease Protein (His) | SARS-CoV-2 | Baculovirus Insect Cells |
3C-like protease (3CLpro) is the main protease of Humann Coronavirus. 3C-like protease (3CLpro) is a key enzyme, as it cleaves several sites to produce non-structural proteins that are essential for genome replication an... | |||
TMPY-05727 | SARS-CoV-2 3CLpro/3C-like protease Protein (His & Avi) | SARS-CoV-2 | E. coli |
3C-like protease (3CLpro) is the main protease of Humann Coronavirus. 3C-like protease (3CLpro) is a key enzyme, as it cleaves several sites to produce non-structural proteins that are essential for genome replication an... | |||
TMPY-02060 | Human Enterovirus 71 VP0 Protein (His & GST) | EV71 | Baculovirus Insect Cells |
Human enterovirus 71 genome polyprotein is a member of the picornaviruses polyprotein family. It contains two peptidase C3 domains, one RdRp catalytic domain, one SF3 helicase domain. Genome polyprotein is cleaved into t... | |||
TMPH-02314 | XRCC5 Protein, Human, Recombinant (His & MBP) | Human | Baculovirus Insect Cells |
Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA. Required for double-strand break repair and V(D)J recombination. Also has a... | |||
TMPH-02315 | XRCC5 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA. Required for double-strand break repair and V(D)J recombination. Also has a... |
カタログ番号 | 製品名 | ||
---|---|---|---|
L1710 | Anti-COVID-19 Compound Library | 1133 compounds | |
A unique collection of 1133 compounds with confirmed anti-SARS-CoV-2 activity or potential activity and part of them are broad-spectrum antiviral agents; |